The first indirect evidence of the existence of thermal springs comes from archaeological discoveries of the bones of prehistoric animals and settlements by prehistoric people on the bank of the river, people who were attracted to the hot springs. An extremely precious finding from this region is the small statue of the woman carved from a mammoth tusk known as the Moravian Venus. Scientists estimate its age at 22,860 years.

The first written records about Piešťany are found in the Zobor letter from the year 1113. The future fame and international reputation of Piešťany as a spa town started in the second half of the 17th century.

In 1642, Adam Trajan from Benešov, in his poem Saluberrimae Pistinienses Thermae depicted unsurpassed the healing power description of the Piešťany spa.

The first buildings were constructed at the end of the 18th century. In 1821 the owner of Piešťany, Count Jozef Erdödy started building the spa systematically. The first mirror bath in Piešťany – the art nouveau style Napoleon Spa II - was built to treat wounded soldiers after the end of the Napoleonic wars (1822).

One of the most significant personalities who visited Piešťany spa was the Bulgarian Tsar Ferdinand I who was a frequent visitor to the Spa. During his stay in 1917 he formed his general war staff. The German Kaiser Wilhelm II and the last Austrian Kaiser Charles I came to join him at the spa and talk about the progress of the war. Other important guests included the world-famous actress Lillian Gish, Swedish writer and Nobel prize winner for literature Selma Lagerlöff. Significant politicians – Edvard Beneš, Vavro Šrobár, Jan Masaryk. Famous Czech actor and comedian Vlasta Burian the young Austrian composer Johann Strauss junior, the English historian Robert Seaton-Watson, Czech journalist Jaroslav Hašek, famous Russian opera singer Fiodor I Šaljapin. It is also said that Ludwig van Beethoven sought inspiration in the splendid environment of Bacchus Vila.

Piešťany spa is regularly visited by presidents, prime ministers, ministers of European governments as well as famous personalities from cultural life - actresses Claudia Cardinale, Mariann Gundersen, model Claudia Schiffer, sporting personalities such as David Coulthard or Jaromír Jágr.

From 1940 Piešťany spa became a state spa. In 1954 Piešťany was declared a spa town of international importance and construction started on spa town hotels, cultural facilities and transportation. Between the years 1968 and 1980 modern complex of the Balneocentre was built – the hotels Balnea Grand Splendid and Balnea Esplanade Palace offering comfort, healing in Balneorehabilitation II and the Social Centre offering cultural and entertainment.

Today Piešťany offers a maximal commfort and social life for the most demanding guests as well. Nowadays Piešťany Spa is the member of the international group of the spas and hotels - Danubius Hotels Group.